2025:

​

The role of water in mediating DNA structures with epigenetic modifications, higher-order conformations and drug-DNA interactions; Roshan Satange, and Ming-Hon Hou, RSC Chem. Biol., 2025, Advance Article https://doi.org/10.1039/D4CB00308J (JIF=4.2)​

​

Structural and functional insights into targeting GCCG sites in the EGFR promoter by two DNA intercalators to inhibit breast cancer metastasis; Chih-Chun Chang, Hsin-Ju Li, Roshan Satange#, Shan-Meng Lin, Tai-Lin Chen, Chi-Chien Lin, Stephen Neidle, and Ming-Hon Hou, Journal of Medicinal Chemistry, 68, 6, 6601–6615, 03 March 2025 https://doi.org/10.1021/acs.jmedchem.4c03203 (JIF=6.9) (# equal contribution)

 

2024:

​

Antiviral drug development by targeting RNA binding site, oligomerization and nuclear export of influenza nucleoprotein; Sankar Panthi, Jhen-Yi Hong, Roshan Satange, Ching-Ching Yu, Long-Yuan Li, and Ming-Hon Hou, International Journal of Biological Macromolecules, Volume 282, Part 4, 136996, December 2024 https://doi.org/10.1016/j.ijbiomac.2024.136996 (JIF=7.7)

​

Targeting DNA junction sites by bis-intercalators induces topological changes with potent antitumor effects; Shih-Chun Huang, Chia-Wei Chen, Roshan Satange#, Chang-Chih Hsieh, Chih-Chun Chang, Shun-Ching Wang, Chi-Li Peng, Tai-Lin Chen, Ming-Hsi Chiang, Yih-Chern Horng and Ming-Hon Hou, Nucleic Acids Research, Volume 52, Issue 15, 27, 27 August 2024, Pages 9303–9316 https://doi.org/10.1093/nar/gkae643 (JIF=16.6) (# equal contribution)

 

Structural basis of water-mediated cis Watson-Crick/Hoogsteen base-pair formation in non-CpG methylation; Shan-Meng Lin, Hsiang-Ti Huang, Pei-Ju Fang, Chi-Fon Chang, Roshan Satange, Chung-ke Chang, Shan-Ho Chou, Stephen Neidle and Ming-Hon Hou, Nucleic Acids Research, Volume 52, Issue 14, 12 August 2024, Pages 8566–8579 https://doi.org/10.1093/nar/gkae594 (JIF=16.6)

​

2023:

​

Structural basis for water modulating RNA duplex formation in the CUG repeats of myotonic dystrophy type 1; Shun-Ching Wang, Yi-Tsao Chen, Roshan Satange#, Jhih-Wei Chu, and Ming-Hon Hou, Journal of Biological Chemistry, volume 299, issue 7,104864, 26 May 2023 https://doi.org/10.1016/j.jbc.2023.104864 (JIF=4.0) (# equal contribution)

​

Synergistic binding of actinomycin D and echinomycin to DNA mismatch sites and their combined anti-tumour effects; Roshan Satange, Chih-Chun Chang, Long‐Yuan Li, Sheng-Hao Lin, Stephen Neidle, and Ming Hon Hou, Nucleic Acids Research, volume 51, issue 8, 8 May 2023, 3540–3555 https://doi.org/10.1093/nar/gkad156 (JIF=16.6)

 

Editorial: Non-canonical nucleic acid structures, functions and their applications for understanding human genetic diseases; Roshan Satange, Peng Jin, Ming-Hon Hou and Ambadas B. Rode, Frontiers in Genetics, volume 14, 5 April 2023, 1188978. https://doi.org/10.3389/fgene.2023.1188978 (JIF=2.8)

​

2022:

​

Revisiting recent unusual drug-DNA complex structures: implications for cancer and neurological disease diagnostics and therapeutics; Roshan Satange, Ambadas B. Rode, and Ming Hon Hou, Bioorganic & Medicinal Chemistry, volume 76, 15 December 2022, 117094 https://doi.org/10.1016/j.bmc.2022.117094 (JIF=3.3)

 

Staggered intercalation of DNA duplexes with base-pair modulation by two distinct drug molecules induces asymmetric backbone twisting and structure polymorphism; Roshan Satange, Shih-Hao Kao, Ching-Ming Chien, Shan-Ho Chou, Chi-Chien Lin, Stephen Neidle, and Ming-Hon Hou, Nucleic Acids Research, volume 50, issue 15, 26 August 2022, 8867-8881 https://doi.org/10.1093/nar/gkac629 (JIF=16.6)

 

2021:

​

Targeting the ALS/FTD-associated A-DNA kink with anthracene-based metal complex causes DNA backbone straightening and groove contraction; Cyong-Ru Jhan, Roshan Satange#, Shun-Ching Wang, Jing-Yi Zeng, Yih-Chern Horng, Peng Jin, Stephen Neidle, and Ming-Hon Hou, Nucleic Acids Research, volume 49, issue 16, 20 September 2021, 9526-9538 https://doi.org/10.1093/nar/gkab227 (On Cover) (JIF=16.6) (# equal contribution)

 

Targeting protein-protein interaction interfaces in COVID-19 drug discovery; Chung-ke Chang, Shan-Meng Lin, Roshan Satange, Shih-Chao Lin, Sin-Cih Sun, Hung-Yi Wu, Kylene Kehn-Hall and Ming-Hon Hou, Computational and Structural Biotechnology Journal, volume 19, 24 April 2021, 2246-2255 https://doi.org/10.1016/j.csbj.2021.04.003 (JIF=4.4)

 

2020:

​

Structural basis for targeting T:T mismatch with triaminotriazine-acridine conjugate induces a U-shaped head-to-head four-way junction in CTG repeat DNA; Ching-Ming Chien, Pei-Ching Wu, Roshan Satange, Cheng-Chun Chang, Zi-Lun Lai, Lauren D. Hagler, Steven C. Zimmerman, and Ming-Hon Hou, Journal of the American Chemical Society, volume 142 (25), 1 June 2020, 11165-11172 https://doi.org/10.1021/jacs.0c03591 (JIF=14.4)

​

2019:

​

Polymorphic G:G mismatches act as hotspots for inducing right-handed Z DNA by DNA intercalation; Roshan Satange, Chien-Ying Chuang, Stephen Neidle, and Ming-Hon Hou, Nucleic Acids Research, volume 47, issue 16, 19 September 2019, 8899-8912 https://doi.org/10.1093/nar/gkz653 (JIF=16.6)

 

2018:

​​

CoII(Chromomycin)2 complex induces a conformational change of CCG repeats from i-Motif to base extruded DNA duplex; Yu-Wen Chen, Roshan Satange, Pei-Ching Wu, Cyong-Ru Jhan, Chung-ke Chang, Kuang-Ren Chung, Michael J. Waring, Sheng-Wei Lin, Li-Ching Hsieh, and Ming-Hon Hou, International Journal of Molecular Sciences, 19(9), 17 September 2018, 2796 https://doi.org/10.3390/ijms19092796 (JIF=4.9)

​

A survey of recent unusual high-resolution DNA structures provoked by mismatches, repeats and ligand binding; Roshan Satange, Chung-ke Chang, and Ming-Hon Hou, Nucleic Acids Research, volume 46, issue 13, 27 July 2018, 6416-6434. https://doi.org/10.1093/nar/gky561 (JIF=16.6)

 

Binding of Small Molecules to Trinucleotide DNA Repeats Associated with Neurodegenerative Diseases; Ming-Hon Hou, Roshan Satange, and Chung-Ke Chang, Chemical Biology No. 7, DNA-targeting Molecules as Therapeutic Agents, The Royal Society of Chemistry, Chapter 6, 08 Mar 2018, 144-174 https://doi.org/10.1039/9781788012928-00144