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Welcome to the Biomolecular Structures and Drug Development Laboratory webpage.​

​​Our laboratory is dedicated to exploring the structural intricacies of biomolecules, including nucleic acids and proteins, to advance drug development and therapeutic innovation. By integrating structural biology, biochemical, biophysical and cellular methods, we aim to uncover the mechanisms of disease-related targets and develop precision drug candidates. Our research focuses on disease-related biomolecules and their interactions with small molecules for translational applications in cancer and neurodegenerative diseases.

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嗨!歡迎來到長庚大學天然物研究所的 生物分子結構暨藥物開發研究室 網頁

​本實驗室致力於探索生物分子(包括核酸與蛋白質)的結構奧秘,以推動藥物開發與治療創新。我們結合結構生物學、生物化學、生物物理學與細胞技術,旨在揭示與疾病相關標的的作用機制,並開發精準藥物候選分子。我們的研究聚焦於與疾病相關的DNA、RNA、蛋白質及其與小分子的互作,期望應用於癌症與神經疾病的轉譯醫學研究 。

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Our research interests

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Roles of Non-Canonical Nucleic Acid Structures in Human Diseases

Cellular Protein-Nucleic Acid Interactions

Development of Targeted Therapeutic Agents

Nucleotide-Repeat Expansion Structures

Hairpins

G-quadruplexes

DNA breaks, Lesions, Mismatch Related Structures

New Therapeutic Strategies

Understanding Disease Mechanims

Protein

Protein

High-throughput Approaches

Drug-Repurposing

Small Molecule Screening

Protein-Nucleic Acid Interaction Targeting

Sequence-Specific Targeting

Structure-Specific Targeting

Rational Design of Nucleic Acid Therapeutics

Biological Effects

Clinical Applications

Our approach

Structure-Based Studies

Biophysical Studies

Biological Evaluation

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UV-Vis

CD

Fluorescence

ITC, SPR

X-ray crystallography

Rational Design

In vitro

In vivo

High-throughput Screening

Binding Affinity

Molecular Dynamics Simulations

Graduate Institute of Natural Products, Chang Gung University, 3rd Floor, Second Medical Building, No.259, Wenhua 1st Rd., Guishan District, Taoyuan City 33302, Taiwan.

長庚大學天然藥物所  33302桃園縣龜山鄉文化一路259 號 第二醫學大樓三樓

+886-3-2118800 ext 3212 (Office), ext 5523 (Lab)

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