
Welcome to Dr. Satange's
Biomolecular Structures and Drug Development Laboratory
(生物分子結構暨藥物開發研究室)
Hi! Welcome to the Biomolecular Structures and Drug Development Laboratory webpage at the Graduate Institute of Natural Products, Chang Gung University.
Our laboratory is dedicated to exploring the structural intricacies of biomolecules, including nucleic acids and proteins to advance drug development and therapeutic innovation. By integrating structural biology, biochemical, biophysical and cellular methods, we aim to uncover the mechanisms of disease-related targets and develop precision drug candidates. Our research focuses on disease-related DNA, RNA, proteins, and their interactions with small molecules for translational applications in cancer and neurological diseases.
嗨!歡迎來到長庚大學天然物研究所的 生物分子結構暨藥物開發研究室 網頁。
本實驗室致力於探索生物分子(包括核酸與蛋白質)的結構奧秘,以推動藥物開發與治療創新。我們結合結構生物學、生物化學、生物物理學與細胞技術,旨在揭示與疾病相關標的的作用機制,並開發精準藥物候選分子。我們的研究聚焦於與疾病相關的DNA、RNA、蛋白質及其與小分子的互作,期望應用於癌症與神經疾病的轉譯醫學研究 。

Our research interests

Structural basis of disease-associated non-canonical DNA and RNA
Cellular protein interactions with disease-associated DNA and RNA
Nucleotide repeat-expansion related structures
Quadruplexes
Hairpin structures
DNA breaks, lesions, base-pair mismatches
Understanding disease mechanisms
New therapeutic strategies

Development of new therapeutic agents targeting disease-associated non-canonical DNA/RNA structures and nucleic acid-protein interactions
High-throughput screening
Drug-repurposing
Small molecule screening
Protein targeting agents
Sequence-specific nucleic acid targeting
Structure-specific nucleic acid targeting
Biological effects
Applications
Our approach
Structure-based studies
Biophysical studies
Biological evaluation

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X-ray crystallography (X射線晶體學)
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Structure-based drug design
(基於分子結構分析的藥物設計與開發)
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Molecular modelling and simulations
(分子結構建模與動力學模擬)
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UV-Vis spectroscopy (紫外光-可見光光譜分析)
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Fluorescence spectroscopy (螢光光譜學)
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Circular dichroism spectroscopy (圓二色光譜儀)
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Binding affinity analysis (分子結合親和力分析)
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In vitro and in vivo studies
(體外實驗與體內實驗研究)
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Biological evaluation of potential drug candidates
(以評估潛在藥物候選物之生物學意義)