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Hi! Welcome to the Biomolecular Structures and Drug Development Laboratory webpage at the Graduate Institute of Natural Products, Chang Gung University.​

Our laboratory is dedicated to exploring the structural intricacies of biomolecules, including nucleic acids and proteins to advance drug development and therapeutic innovation. By integrating structural biology, biochemical, biophysical and cellular methods, we aim to uncover the mechanisms of disease-related targets and develop precision drug candidates. Our research focuses on disease-related DNA, RNA, proteins, and their interactions with small molecules for translational applications in cancer and neurological diseases.

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嗨!歡迎來到長庚大學天然物研究所的 生物分子結構暨藥物開發研究室 網頁

​本實驗室致力於探索生物分子(包括核酸與蛋白質)的結構奧秘,以推動藥物開發與治療創新。我們結合結構生物學、生物化學、生物物理學與細胞技術,旨在揭示與疾病相關標的的作用機制,並開發精準藥物候選分子。我們的研究聚焦於與疾病相關的DNA、RNA、蛋白質及其與小分子的互作,期望應用於癌症與神經疾病的轉譯醫學研究 。

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Our research interests

Structural basis of disease-associated non-canonical DNA and RNA

Cellular protein interactions with disease-associated DNA and RNA

Nucleotide repeat-expansion related structures

Quadruplexes

Hairpin structures

DNA breaks, lesions, base-pair mismatches

Understanding disease mechanisms

New therapeutic strategies

Development of new therapeutic agents targeting disease-associated non-canonical DNA/RNA structures and nucleic acid-protein interactions

High-throughput screening

Drug-repurposing

Small molecule screening

Protein targeting agents

Sequence-specific nucleic acid targeting

Structure-specific nucleic acid targeting

Biological effects

Applications

Our approach

Structure-based studies

Biophysical studies

Biological evaluation

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  • X-ray crystallography (X射線晶體學)

  • Structure-based drug design 

       (基於分子結構分析的藥物設計與開發)

  • Molecular modelling and simulations

       (分子結構建模與動力學模擬)

  • UV-Vis spectroscopy (紫外光-可見光光譜分析)

  • Fluorescence spectroscopy (螢光光譜學)

  • Circular dichroism spectroscopy (圓二色光譜儀)

  • Binding affinity analysis (分子結合親和力分析)

  • In vitro and in vivo studies

       (體外實驗與體內實驗研究)

  • Biological evaluation of potential drug candidates

       (以評估潛在藥物候選物之生物學意義)

News & Events

Coming soon...

Graduate Institute of Natural Products, Chang Gung University, 3rd Floor, Second Medical Building, No.259, Wenhua 1st Rd., Guishan District, Taoyuan City 33302, Taiwan.

長庚大學天然藥物所  33302桃園縣龜山鄉文化一路259 號 第二醫學大樓三樓

+886-3-2118800 ext 3212 (Office), ext 5523 (Lab)

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